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UCI Publications



114. Luo, X., Xing, W., Delcheva, I., Abdullah Alrashaidi, F., Heydari, A., Palms, D., Truong, V.K., Vasilev, K., Jia, Z., Zhang, W., Su, P., Vimalanathan, K., Igder, A., Weiss, G.A., Tang, Y., MacGregor, M., Raston, C.L. (2023). Printable hydrogel arrays for portable and high-throughput shear-mediated assays. ACS Appl. Mater. Interfaces. 15: 31114-31123.

113. Sanders, E.C., Santos, A.M.,  Nguyen, E.K., Gelston, A.A. Majumdar, S., Weiss, G.A.* (2023). Phage vs. Phage: Direct selections of sandwich binding pairs. Viruses. 15: 807.


112. Spano, M.B., Pamidi, A.S., Weiss, G.A.* (2023). An open source, 3D-printed TrapGuard to protect oil-sealed vacuum pumps from cold trap warming. J. Org. Chem. 88: 1215-1218. Published as a “Note” and featured on the journal cover.



111. King, E., Maxel, S., Zhang, Y., Kenney, K., Cui, Y., Luu, E., Siegel, Ju., Weiss, G.A., Luo, R., Li, H.* (2022). Orthogonal glycolytic pathway enables directed evolution of noncanonical cofactor oxidase. Nat. Commun. 13: 7282.

110. Sen, S.R., Sanders, E.C., Santos, A.M., Bhuvan, K., Tang, D.Y., Gelston, A.A., Miller, B.M., Ricks-Oddie, J.L., Weiss, G.A.* (2022). Evidence for deleterious original antigenic sin in SARS-CoV-2 immune response. PLOS ONE. 17: e0272163.

109. Dyer, R.P., Isoda, H.M., Salcedo, G.S., Speciale, G., Fletcher, M.H., Le, L.Q., Liu, Y., Brami-Cherrier, K., Malik, S.Z., Vazquez-Cintron, E.J., Chu, A.C., Rupp, D.C., Jacky, B.P.S., Nguyen, T.T.M., Katz, B.B., Steward, L.E., Majumdar, S., Brideau-Andersen, A.D.*, Weiss, G.A.* (2022). Reengineering the specificity of the highly selective Clostridium botulinum protease via directed evolution. Scientific Reports. 12: 9956.

108. Sanders, E.C., Sen, S.R., Gelston, A.A., Santos, A.M., Luo, X., Bhuvan, K., Tang, D.Y., Raston, C.L., Weiss, G.A.* (2022). Under-5-minute immunoblot assays by Vortex Fluidic Device acceleration. Angew. Chem. Int. Ed. 61: e202202021. †Co-equal contributors.

107. Turvey, M.W.†, Gabriel, K.N.†, Lee, W., Taulbee, J.J., Kim, J.K., Chen, S., Lau, C.J., Kattan, R.E., Pham, J.T., Majumdar, S., Garcia, D., Weiss, G.A.*, Collins, P.G.* (2022). Single-Molecule Taq DNA polymerase dynamics. Science Advances. 8: eabl3522. †Co-equal contributors.


106. Dyer, R.P., Weiss, G.A.* (2022). Making the cut with protease engineering. Cell Chem. Biol. 29:177-190. Review.


105. Bhasin, A., Coi, E.J., Drago, N.P., Garrido, J.E., Sanders, E.C., Shin, J., Andoni, I., Kim, D.-H., Fang, L., Weiss, G.A.*, Penner, R.M.* (2021) Enhancing the sensitivity of the virus BioResistor by over-oxidization: Detecting IgG antibodies. Anal. Chem. 93: 11259-11267.

104. Sen, S.R.†, Sanders, E.C.†, Gabriel, K.N.†, Miller, B.M., Isoda, H.M., Salcedo, G.S., Garrido, J.E., Dyer, R.P., Nakajima, R., Jain, A., Santos, A.M., Bhuvan, K., Tifrea, D.F., Ricks-Oddie, J.L., Felgner, P.L., Edwards, R.A., Majumdar, S., Weiss, G.A.* (2021). Predicting COVID-19 severity with a specific nucleocapsid antibody plus disease risk factor score. mSphere. 6: e00203-e00221. †Co-equal contributors.

103. Lee, S.-H., Moody, I., Zeng, Z., Fleischer, E.B., Weiss, G.A., Kenneth J. Shea* (2021). Synthesis of a high affinity complementary peptide–polymer nanoparticle (NP) pair using phage display. ACS Appl. Bio. Mater. 4: 2704–2712. 


102. Luo, X., Al-Antaki, A.H.M., Igder, A., Stubbs, K.A., Su, P., Zhang, W., Weiss, G.A., Raston, C.L. (2020). Vortex fluidic-mediated fabrication of fast gelated silica hydrogels with embedded laccase nanoflowers for real-time biosensing under flow. ACS Appl Mater Interfaces. 12: 51999-52007.

101. Bhasin, A., Drago, N.P., Majumdar, S., Sanders, E.C., Weiss, G.A.*, Penner, R.M.* (2020). Viruses masquerading as antibodies in biosensors:  The development of the Virus BioResistor. Acc. Chem. Res. 53: 2384-2394. Review.

100. Spano, M.B., Tran, B.H., Majumdar, S., Weiss, G.A.* (2020) 3D-printed labware for high-throughput immobilization of enzymes. J. Org. Chem. 85: 8480-8488.

99. Nguyen, D., Behrens, D.M.**, Sen, S.**, Najdahmadi, A., Pham, J.N., Speciale, G., Lawrence, M.M., Majumdar, S., Weiss, G.A.*, Botvinick, E.L.* (2020) A photo-stable and proteolysis-resistant FRET-based calcium biosensor. Anal. Chem. 92: 7683–7689. **Co-equal contributors.

98. Richardson, M.B., Gabriel, K.N., Garcia, J.A., Ashby, S.N., Dyer, R.P., Kim, J.K., Lau, C.J., Hong, J., Le Tourneau, R.J., Sen, S., Narel, D.L., Katz, B.B., Ziller, J.W., Majumdar, S., Collins, P.G., Weiss, G.A.* (2020). Pyrocinchonimides conjugate to amine groups on proteins via imide transfer. Bioconjugate Chem. 31: 1449-1462.

97. Bhasin, A., Sanders, E.C., Ziegler, J.M., Briggs, J.S., Drago, N.P., Attar, A.M., Santos, A.M., True, M.Y., Ogata, A.F., Yoon, D.V., Majumdar, S., Wheat, A.J., Patterson, S.V., Weiss, G.A., Penner, R.M.* (2020). Virus BioResistor (VBR) for the detection of the bladder cancer marker DJ-1 in urine at 10 pM in one minute. Anal. Chem. 92: 6654-6666.

96.Totoiu, C.A., Phillips, J.M., Reese, A.T., Majumdar, S., Girguis, P.R., Raston, C.L, Weiss, G.A.* (2020). Vortex fluidics-mediated DNA rescue from formalin-fixed museum specimens. PLOS One. 15: e0225807.


95. Attar, A.M., Richardson, M.B., Speciale, G., Majumdar, S., Dyer, R.P., Sanders, E.C., Penner, R.M.*, Weiss, G.A.*(2019). Electrochemical quantification of glycated and non-glycated human serum albumin in synthetic urine. ACS Appl. Mater. Inter. 11: 4757–4765.


94. Hoffmann, K., Milech, N., Juraja, S.M., Cunningham, P.T., Stone, S.R., Francis, R.W., Anastasas, M., Hall, C.M., Heinrich, T., Bogdawa, H.M., Winslow, S., Scobie, M.N., Dewhurst, R.E., Florez, L., Ong, F., Kerfoot, M., Champain, D., Adams, A.M., Fletcher, S., Viola, H.M., Hool, L.C., Connor, T., Longville, B.A.C., Tan, Y.-F., Kroeger, K., Morath, V.,Weiss, G.A., Skerra, A., Hopkins, R.M., Watt, P.M. (2018). A platform for discovery of functional cell-penetrating peptides for efficient multi-cargo intracellular delivery. Sci. Rep. 8: 12538.

93. Britton, J.*, Majumdar, S., Weiss, G.A.*(2018). Continuous flow biocatalysis. Chem. Soc. Rev. 47:5891-5918.

92. Smith, J.N., Edgar, J.M., Iftikhar, M. Fong, J.C., Balk, J.M., Olsen, T.J., Majumdar, S., Fishman, D.A., Weiss, G.A.* (2018). Directed evolution and biophysical characterization of a full-length, soluble, human caveolin-1 variant. BBA - Proteins Proteom. 1866: 963-972.

91. Bhasin, A., Ogata, A.F., Briggs, J., Tam, P.Y., Tan, M.X., Weiss, G.A.*Penner, R.M.* (2018). The Virus BioResistor:  Wiring virus particles for the direct, label-free detection of target proteins. Nano Lett. 18: 3623-3629.

90. Richardson, M.B.*, Brown, D.B., Vasquez, C.A., Ziller, J.W., Johnston, K.M., Weiss, G.A.* (2018). Synthesis and explosion hazards of 4-azido-L-phenylalanine. J. Org. Chem. 83: 4525-4536. Reported in Chem.& Eng. News by Carmen Drahl on April 9, 2018. Commentary by Derek Lowe’s “In the Pipeline" blog on April 27, 2018.



89. Weiss, G.A.* (2017). Editorial overview: How to generate molecular diversity, the most important process in biology. Curr. Opin. Chem. Biol. 41: A3-A5.  

88. Pugliese, K.P.*, Weiss, G.A.* (2017). Recent progress in dissecting molecular recognition by DNA polymerases with non-native substrates. Curr. Opin. Chem. Biol. 41: 43-49.

87. Meneghini, L.M., Tripathi, S., Woodworth, M.A., Majumdar, S., Poulos, T.L., Weiss, G.A.* (2017). Dissecting binding of a β-barrel membrane protein by phage display. Mol. Biosyst. 13: 1438-1447.


86. Britton, J., Stubbs, K.A., Weiss, G.A.*, Raston, C.L.* (2017). Vortex fluidic chemical transformations. Chem.-Eur. J. 23: 13270-13278.

85. Britton, J., Dyer, R.P., Majumdar, S., Raston, C.L.*, Weiss, G.A.* (2017). Ten-minute protein purification and surface tethering for continuous-flow biocatalysis. Angew. Chem. Int. Ed. Engl. 56: 2296-2301.

84. Ogata, A., Edgar, J.M., Majumdar, S., Briggs, J.S., Patterson, S., Tan, M.X., Kudlacek, S.T., Schneider, C.A., Weiss, G.A.*, Penner, R.M.* (2017). A virus-enabled biosensor for human serum albumin. Anal. Chem. 89: 1373-1381.

83. Britton, J., Smith, J.N., Raston, C.L.*, Weiss, G.A.* (2017). Protein folding using a vortex fuidic device. Methods Mol. Biol. 1586: 211-220.


82. Britton, J., Raston, C.L.*, Weiss, G.A.* (2016). Rapid protein immobilization for thin film continuous flow biocatalysis. Chem. Commun. 52: 10159-10162.

81. Britton, J., Meneghini, L.M., Raston, C.L.*, Weiss, G.A.* (2016). Accelerating enzymatic catalysis using vortex fluidics. Angew. Chem. Int. Ed. 55: 11387-11391.

80. Gul, O.T., Pugliese, K.M., Choi, Y., Sims, P.C., Pan, D., Rajapakse, A.J., Weiss, G.A.*, Collins, P.G.* (2016). Single molecule bioelectronics and their application to amplification-free measurement of DNA lengths. Biosensors. 6: 29. Special Issue on Graphene and Carbon Nanotube Based Biosensors.

79. Britton, J., Castle, J.W., Weiss, G.A.*, Raston, C.L.* (2016).  Harnessing thin film continuous flow assembly lines. Chem.-Eur. J. 22: 10773-10776.

78. Gilliam, A.J.H., Smith, J.N., Flather, D., Johnston, K.M., Gansmiller, A.M., Fishman, D.A., Edgar, J.M., Balk, M., Majumdar, S., Weiss, G.A. (2016). Affinity-guided design of caveolin-1 ligands for deoligomerization. J. Med. Chem. 59: 4019-4025.

77. Mohan, K., Weiss, G.A.* (2016). Chemically modifying viruses for diverse applications. ACS Chem. Biol. 11: 1167-1169.


76. Mohan, K., Weiss, G.A.* (2015). Engineering chemically modified viruses for prostate cancer cell recognition. Mol. Biosyst. 11: 3264-3272. This article is part of themed collection: Chemical Biology in Molecular BioSystems and 2015 Hot Articles in Molecular BioSystems

75. Pugliese, K.M., Gul, O.T., Choi, Y., Olsen, T.J., Sims, P.C., Collins, P.G.*, Weiss, G.A.* (2015). Processive incorporation of deoxynucleoside triphosphate analogs by single-molecule DNA Polymerase I (Klenow Fragment) nanocircuits. J. Amer. Chem. Soc. 137: 9587-9594.

74. Mohan, K., Penner, R.M.*, Weiss, G.A.* (2015). Biosensing with virus electrode hybrids. Curr. Protoc. Chem. Biol. 7: 53-72. 

73. Akhterov, M.V., Choi, Y., Olsen, T.J., Sims, P.C., Iftikhar, M., Gul, O.T., Corso, B.L., Weiss, G.A.*, Collins, P.G.* (2015). Observing lysozyme closing and opening motions by high-resolution single molecule enzymology. ACS Chem. Biol.10: 1495-501. 

72. Yuan, T.Z., Ormonde, C.F.G., Kudlacek, S.T., Kunche, S., Smith, J.N., Brown, W.A., Pugliese, K.M., Olsen, T.J., Iftikhar, M., Raston, C.L.*, Weiss, G.A.* (2015). Shear stress-mediated refolding of proteins from aggregates and inclusion bodies. ChemBioChem. 16: 393-396.  Widely reported in the popular and science media. Altmetric score: 713.

71. Eldridge, G.M.*, Weiss, G.A.* (2015). Identifying reactive peptides from phage-displayed libraries. Methods Mol. Biol. 1248: 189-199.


70. Alhoshani, A., Vithayathil, R., Bandong, J., Chrunyk, K.M., Moreno, G.O., Weiss, G.A., Cocco, M.J.* (2014). Glutamate provides a key structural contact between reticulon-4 (Nogo-66) and phosphocholine. BBA – Biomembranes. 1838: 2350-2356.

69. Mohan, K., Weiss, G.A.* (2014). Dual genetically encoded phage-displayed ligands. Anal. Biochem. 453: 1-3.


68. Sims, P.C., Moody, I.S., Choi, Y., Dong, C., Iftikhar, M., Corso, B.L., Gul, O.T., Collins, P.G.*, Weiss, G.A.* (2013). Electronic measurements of single-molecule catalysis by cAMP-dependent protein kinase A. J. Amer. Chem. Soc. 135: 7861-7868.

67. Olsen, J., Choi, Y., Sims, P.C., Gul, O.T., Corso, B.L., Dong, C. Brown, W.A., Collins, P.G.*, Weiss, G.A.* (2013). Electronic measurements of single-molecule processing by DNA polymerase I (Klenow Fragment). J. Amer. Chem. Soc. 135: 7855-7860. Joint first two authors.

66. Mohan, K., Donavan, K.C., Arter, J.A., Penner, R.M.*, Weiss, G.A.* (2013). Sub-nanomolar detection of prostate specific membrane antigen in synthetic urine by synergistic, dual ligand phage. J. Amer. Chem. Soc. 135: 7761-7767.

65. Choi, Y., Weiss, G.A.*, Collins, P.G.* (2013). Single molecule bioelectronics. Handbook of Bioelectronics. Cambridge University Press. Not peer-reviewed.

64. Choi, Y., Weiss, G.A.*, Collins, P.G.* (2013). Single molecule recordings of lysozyme activity. Phys. Chem. Chem. Phys. 15: 14879-14895. Review. Not peer-reviewed.

63. Choi, Y., Olsen, T.J., Sims, P.C., Moody, I.S., Corso, B.L., Dang, M.N., Weiss, G.A.*, Collins, P.G.* (2013). Dissecting single-molecule signal transduction in carbon nanotube circuits with protein engineering. Nano Lett. 13: 625-631. Joint first two authors.

62. Yuan, T.Z., Overstreet, C.M., Moody, I.S., Weiss, G.A.* (2013). Protein engineering with biosynthesized libraries from Bordetella bronchiseptica bacteriophage. PLOS One. 8: e55617.


61. Donavan, K.C., Arter, J.A., Weiss, G.A.*, Penner, R.M.* (2012). Virus-poly(3,4-ethylenedioxythiophene) biocomposite films. Langmuir 28: 12581-12587. 

60. Moody, I.S., Choi, Y., Olsen, T.J., Sims, P.C., Collins, P.G.*, Weiss, G.A.* (2012).  Dissecting lysozyme by single-molecule techniques. Chapter in Lysozyme: Sources, Functions, and Role in Disease. Nova Science Publishers.  Not peer-reviewed

59. Moody, I.S., Verde, S.C., Overstreet, C.M., Robinson, Jr., W.E.*, Weiss, G.A.* (2012). In vitro evolution of an HIV integrase binding protein from a library of C-terminal gamma-S-crystallin variants. Bioorg. Med. Chem. Lett. 22: 5584-5589.

58. Arter, J.A., Diaz, J.E., Donavan, K.C., Yuan, T., Penner, R.M.*, Weiss, G.A.* (2012). Virus-polymer hybrid nanowires tailored to detect prostate-specific membrane antigen. Anal. Chem. 84: 2776-2783. 

57. Choi, Y., Moody, I.S., Sims, P.C., Hunt, S.R., Corso, B.L., Seitz, D., Blaszczak, L., Collins, P.G.*, Weiss, G.A.* (2012).  Single molecule dynamics of lysozyme processing distinguishes linear and cross-linked peptidoglycan substrates. J. Am. Chem. Soc. 134: 2032-2035.

56. Overstreet, C.M., Yuan, T.Z., Levin, A.M., Kong, C., Coroneus, J.G., Weiss, G.A.* (2012). Self-made phage libraries with heterologous inserts in the Mtd of Bordetella bronchiseptica. Protein Eng. Des. Sel. 25: 145-151.

55. Choi, Y., Moody, I.S., Sims, P.C., Hunt, S.R., Corso, B.L., Perez, I., Weiss, G.A.*, Collins, P.G.* (2012). Single molecule lysozyme dynamics monitored by an electronic circuit. Science. 335: 319-324. Joint first two authors.


54. Vithayathil, R., Hooy, R.M., Cocco, M.J., Weiss, G.A.* (2011). The scope of phage display for membrane proteins. J. Mol. Biol. 414: 499-510.

53. Eldridge, G.M., Weiss, G.A.* (2011). Hydrazide reactive peptide tags for site-specific protein labeling. Bioconjugate Chem. 22: 2143-2153.

52. Diaz, J.E., Lin, C.-S., Kunishiro, K., Feld, B.K., Avrantinis, S.K., Bronson, J., Greaves, J., Saven, J.G., Weiss, G.A.* (2011). Computational design and selections for an engineered, thermostable terpene synthase. Prot. Science. 20: 1597-1606.

51. Majumdar, S., Hajduczki, A., Vithayathil, R., Olsen, T.J., Spitler, R.M., Mendez, A.S., Thompson, T.D., Weiss, G.A.* (2011). In vitro evolution of ligands to the membrane protein caveolin. J. Amer. Chem. Soc. 133: 9855-9862. Joint first two authors.

50. Donavan, K., Arter, J., Pilolli, R., Cioffi, N., Weiss, G.A.*, Penner, R.M.* (2011). Virus-PEDOT composite films for impedance-based biosensing. Anal. Chem. 83: 2420-2424.

49. Loo, Y.-H., Weiss, G.A., Alper, H. (2011). Building successful university-business partnerships.  Chem. Eng. Prog. 107: 6. Not peer-reviewed.

48. Hajduczki, A., Majumdar, S., Fricke, M., Brown, I.A.M., Weiss, G.A.* (2011). Solubilization of a membrane protein by combinatorial supercharging. ACS Chem. Biol. 6: 301-307. Joint first two authors.


47. Arter, J.A., Taggart, D.K., McIntire, T.M., Penner, R.M.*, Weiss, G.A.* (2010). Virus-PEDOT nanowires for biosensing.  Nano Lett. 10: 4858-4862. 

46. Brück, T., Beaudry, C., Hilgenkamp, H. Karoonuthaisiri, N., Salah-Eldin Mohamed, H., Weiss, G.A. (2010). Empowering young scientists. Science 328: 17.  Editorial.


45. Lamboy, J.A., Arter, J.A., Knopp, K.A., Der, D., Overstreet, C.M., Palermo, E., Urakami, H., Yu, T.-B., Tezgel, O., Tew, G.N., Guan, Z., Kuroda, K., Weiss, G.A.* (2009). Phage wrapping with cationic polymers eliminates non-specific binding between M13 phage and high pI target proteins. J. Amer. Chem. Soc. 131:16454-16460. Supplementary Materials


44. Lamboy, J.A., Tam, P.Y., Lee, L.S., Jackson, P.J., Avrantinis, S.K., Lee, H.J., Corn, R.M., Weiss, G.A. (2008). Chemical and genetic wrappers for improved phage and RNA display. ChemBioChem. 9: 2846-2852. Featured on the journal cover. Supplementary Materials

43. Majumdar, S., Hajduczki, A., Mendez, A.S., Weiss, G.A.* (2008). Phage display of functional, full-length human and viral membrane proteins. Bioorg. Med. Chem. Lett. 8: 5937-5940. Joint first two authors.

42. Yang, L.-M., Diaz, J.E., McIntire, T., Weiss, G.A.*, Penner, R.M.* (2008). Direct electrical transduction of antibody binding to a covalent virus layer using electrochemical impedance. Anal. Chem. 80: 5695-5705. Accelerated article. 

41. Coroneus, J.G., Goldsmith, B., Lamboy, J.A., Kane, A.A., Collins, P.G.*, Weiss, G.A.* (2008). Mechanism-guided improvements to the single molecule oxidation carbon nanotube sidewalls. ChemPhysChem. 9: 1053-1056.

40. Weiss, G.A.*, Penner, R.M.* (2008). The promise of phage display: customized affinity and specificity. Anal. Chem. 80: 3082-3089. Featured on the journal cover. Review.

39. Goldsmith, B.R., Coroneus, J.G., Kane, A.A., Weiss, G.A., Collins, P.G.* (2008). Monitoring single molecule reactivity on a carbon nanotube. Nano Lett. 8: 189-194.

38. Yang, L.-M.C., Diaz, J.E., McIntire, T.M., Weiss, G.A.*, Penner, R.M.* (2008). Covalent virus layers for mass-based detection. Anal. Chem. 80: 933-943.

37. Diaz, J.E., Yang, L.-M.C., Lamboy, J.A., Penner, R.M.*, Weiss, G.A.* (2008). Synthesis of a virus electrode for measurement of prostate specific membrane antigen. Methods Mol. Biol. 504: 255-274.

36. Goldsmith, B., Coroneus, J.G., Weiss, G.A., Collins, P.G.* (2008). Scaffolding carbon nanotubes into single-molecules circuitry. J. Mater. Res. 1018: 1018-EE08-07.


35. Weiss, G.A. (2007). Exploring the Milky Way of molecular diversity: Combinatorial chemistry and molecular diversity. Curr. Opin. Chem. Biol. 11: 241-243.

34. Levin, A.M., Murase, K., Jackson, P.J., Flinspach, M.L., Poulos, T.L., Weiss, G.A.* (2007). Double barrel shotgun scanning of the caveolin-1 scaffolding domain. ACS Chem. Biol.  2: 493-500. Joint first two authors. Featured on the journal cover.

33. Goldsmith, B., Coroneus, J.G., Khalap, V.R., Kane, A.A., Weiss, G.A., Collins, P.G.* (2007). Conductance-controlled point functionalization of single-walled carbon nanotubes. Science. 315: 77-81. Featured in Chemistry & Engineering News. Erratum in Science (2007) 318: 1866. 


32. Yang, L.-M.C., Tam, P.Y., Murray, B.J., McIntire, T.M., Overstreet, C.M., Weiss, G.A.,* Penner, R.M.* (2006). Virus electrodes for universal biodetection. Anal. Chem. 78: 3265-3270. *Corresponding authors. Featured on the journal cover. 

31. Levin, A.M., Coroneus, J.G., Cocco, M.J., Weiss, G.A.* (2006). Exploring the interaction between the protein kinase A catalytic subunit and Caveolin-1 scaffolding domain with shotgun scanning, oligomer complementation, NMR, and docking. Prot. Science. 15: 478-486.

30. Feld, B.K., Weiss, G.A.* (2006). Improved syntheses of P1-allyl-P2-substituted diphosphates. Bioorg. Med. Chem. Lett. 16: 1665-1667.

29. Morrison, K.L., Weiss, G.A.* (2006). The origins of chemical biology. Nat. Chem. Biol. 2: 3-6.

28. Levin, A.M., Weiss, G.A.* (2006). Optimizing the affinity and specificity of proteins with molecular display. Mol. BioSystems. 2: 49-57.


27. Olszewski, A., Weiss, G.A.* (2005). Library versus library recognition and inhibition of the HIV-1 Nef allelome. J. Am. Chem. Soc. 127: 12178-12179.


26. Wassman, C.D., Tam, P.Y., Lathrop, R.H., Weiss, G.A.* (2004). Predicting oligonucleotide-directed mutagenesis failures in protein engineering. Nucleic Acids Res. 32: 6407-6413. Joint first two authors. 

25. Olszewski, A., Sato, K., Aron, Z.D., Cohen, F., Harris, A., McDougall, B.R, Robinson, Jr., W.E., Overman, L.E., Weiss, G.A.* (2004). Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin and p56lck. Proc. Natl. Acad. Sci. USA. 101: 14079-14084.

24. Simon, M.D., Sato, K., Weiss, G.A., Shokat, K.M. (2004). A phage display selection of engrailed homeodomain mutants and the importance of residue Q50. Nucleic Acids Res. 32: 3623-3631. 

23. Sato, K., Simon, M.D., Levin, A.M., Shokat, K.M., Weiss, G.A. (2004). Dissecting the engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. Chem. Biol. 11:1017-1023. Featured on the journal coverPreview by Scot Wolfe (2004). Chem. Biol. 11: 889-891. 


22. Diaz, J.E., Howard, B.E., Neubauer, M.S., Olszewski, A., Weiss, G.A.* (2003). Exploring biochemistry and cellular biology with protein libraries. Curr. Issues Mol. Biol. 5: 129-146.

21. Weiss, G.A., Chamberlin, A.R. (2003). Bridging the synthetic and biopolymer worlds with peptide-drug conjugates. Chem. Biol. 10: 201-202. 

20. Murase, K., Morrison, K.L., Tam, P.Y., Stafford, R.L., Jurnak, F., Weiss, G.A.* (2003). EF-Tu binding peptides identified, dissected and affinity optimized by phage display. Chem. Biol. 10: 161-168.

19. Sidhu, S.S.*, Feld, B.K., Weiss, G.A.* (2007). M13 bacteriophage coat proteins engineered for improved phage display. Methods Mol. Biol. 352: 205-219.


18. Avrantinis, S.K., Weiss, G.A.* (2002). Dissecting protein functional epitopes with phage display. Phage Display in Biotechnology and Drug Discovery, Taylor & Francis Group, LLC (Sidhu, S.S., ed.), pp. 441-460.

17. Avrantinis, S.K., Stafford, R., Tian, X., Weiss, G.A.* (2002). Dissecting the streptavidin-biotin interaction by phage-displayed shotgun scanning. ChemBioChem. 3: 1229-1234.

16. Weiss, G.A. (2001). Leading the way: training future chemical biologists. Chem. Innovation. 31: 3-4. 

15. Morrison, K.L., Weiss, G.A.* (2001). Combinatorial alanine scanning. Curr. Opin. Chem. Biol. 5: 302-307. 

Genentech Publications

Genentech Publications


14. Sidhu, S.S., Weiss, G.A. (2004). Chapter 2. Constructing phage display libraries by oligonucleotide-directed mutagenesis. Phage Display: A Practical Approach, Oxford University Press (Lowman, H.L. & Clackson, T., eds.), pp. 27-41.  

13. Weiss, G.A., Roth, T.A., Baldi, P.F., Sidhu, S.S. (2003). Comprehensive mutagenesis of the C-terminal domain of the gene-3 minor coat protein: the requirements for assembly into the bacteriophage particle. J. Mol. Biol. 332: 777-782. 

12. Roth, T.A., Weiss, G.A., Eigenbrot, C., Sidhu, S.S. (2002). A minimized M13 coat protein defines the minimum requirements for assembly into the bacteriophage particle. J. Mol. Biol. 322: 357-367.

11. Sidhu, S.S., Weiss, G.A. (2001). Engineered micro-organisms as sources of new drugs. Anticancer Drug Development, Academic Press (Baguley, B. & Kerr, D., eds.), pp. 237-248. 

10. Weiss, G.A., Lowman, H.B. (2000). Anticalins versus antibodies: made-to-order binding proteins for small molecules. Chem. Biol. 7: R177-R184. 

9. Weiss, G.A., Watanabe, C.K., Goddard, A., Zhang, A., Sidhu, S.S. (2000). Rapid mapping of functional protein epitopes by combinatorial alanine-scanning. Proc. Natl. Acad. Sci. USA. 97: 8950-8954.

8. Weiss, G.A., Sidhu, S.S. (2000). Design and evolution of artificial M13 coat proteins. J. Mol. Biol. 300: 213-219.

7. Weiss, G.A., Sidhu, S.S., Wells, J.A. (2000). Mutational analysis of the major coat protein of M13 identifies residues that control protein display. Protein Sci. 9: 647-654.

6. Sidhu, S.S., Weiss, G.A., Wells, J.A. (2000). High copy display of large proteins on M13 phage for functional selections. J. Mol. Biol. 296: 487-495. 

Harvard and U.C. Berkeley Publications

5. Evensen, E., Joseph-McCarthy, D., Weiss, G.A., Schreiber, S.L., Karplus, M. (2007). Ligand design by a combinatorial approach based on modeling and experiment: application to HLA-DR4. J. Comput. Aided Mol. Des. 21: 395-418.

4. Weiss, G.A., Valentekovich, R.J., Collins, E.J., Garboczi, D.N., Schreiber, S.L., Wiley, D.C. (1996). Covalent HLA-B27/peptide complex induced by specific recognition of an aziridine mimic of arginine. Proc. Natl. Acad. Sci. USA 93: 10945-10948. 

3. Weiss, G.A., Collins, E.J., Garboczi, D.N., Wiley, D.C., Schreiber, S.L. (1995). A tricyclic ring system replaces the variable regions of peptides presented by three alleles of human MHC class I molecules. Chem. Biol. 2: 401-407. 

2. Bartlett, P.A., Lauri, G., Weiss, G. (1993). CAVEAT, ILIAD, and TRIAD: 3D Searching for molecular design. J. Mol. Graphics. 11, 271.

1. Karo, A.M., Deboni, T.M., Hardy, J.R., Weiss, G.A. (1990). Shock dynamics in the subnanometer femtosecond domain. Int. J. Quant. Chem. S24: 277-289. 


Van Vranken, D. and Weiss, G.A. Introduction to Bioorganic Chemistry and Chemical Biology (Garland Science, 1st Edition published November 16, 2012). Purchase on

Please email gweiss [at], if you cannot obtain a PDF from the links below.

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